| abstract |
It is an object of the present invention to provide a compound having an intestinal phosphate transporter (NPT-IIb) inhibitory action and useful as an active ingredient of a therapeutic and / or prophylactic agent for hyperphosphatemia. The tetrahydrobenzothiophene compound of the following formula (I) has an NPT-IIb inhibitory action and can be used as a prophylactic and / or therapeutic agent for hyperphosphatemia. (Wherein R 1 is —O-lower alkyl, -lower alkylene-phenyl, etc., and R 2 and R 3 are the same or different and are H, lower alkyl, cycloalkyl, aryl, heteroaryl, etc. Alternatively, R 2 and R 3 may be combined with a nitrogen atom to form a 5- to 7-membered saturated cyclic amino, and R 4 may be the same or different, and may be halogen, lower alkyl, or the like. , N is 0-2.) |