abstract |
Providing vaccinia virus that specifically grows in cancer cells and destroys cancer cells, and the use of the virus for cancer treatment. A vaccinia virus in which a target sequence of a microRNA whose expression is reduced in cancer cells compared to normal cells is inserted into the 3 ′ untranslated region of the B5R gene involved in virus growth, which is specific in the cancer cells A microRNA-regulated vaccinia virus that has an oncolytic property that proliferates and destroys cancer cells. |