| abstract |
The following general formula (I) [Chemical 1] [Wherein, A represents a C3 to C12 cycloalkyl group optionally substituted with 1 to 3 groups selected from a fluoro group, a hydroxyl group, a C1 to C6 alkyl group, etc., and R 1 , R 2 and R 3 each represents Independently represents a hydrogen atom, a fluoro group or a C1-C6 alkyl group, R 4 represents a hydrogen atom or a prodrug group, Y represents —CH 2 —CHR 5 —CH 2 —NHR 6 (where R 5 represents A hydrogen atom, a C1-C6 alkyl group or a C1-C6 alkoxy group, and R 6 represents a hydrogen atom or a prodrug group. Or a pharmacologically acceptable salt thereof has a TAFIa enzyme inhibitory activity, such as myocardial infarction, angina pectoris, acute coronary syndrome, cerebral infarction, deep vein thrombosis, pulmonary embolism, etc. Useful as a therapeutic agent. |