| abstract |
Compounds useful as vascular endothelial lipase inhibitors are provided. formula: (Where Ring A is an aromatic carbocycle or aromatic heterocycle, Z is —NR 5 —, —O— or —S—, R 5 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aryl R 1 is hydrogen, halogen, hydroxy, cyano, nitro, carboxy, substituted or unsubstituted alkyl, etc., R 2 and R 3 are each independently hydrogen, halogen, hydroxy, etc. 4 is a formula: — (CR 6 R 7 ) n—R 8 (wherein R 6 and R 7 are each independently hydrogen, halogen, hydroxy, etc., n is an integer of 0 to 3; 8 carboxy, cyano, a group represented by a.) alkyl and substituted or unsubstituted, R x is halogen, hydroxy, cyano, nitro, carboxy, alkyl and substituted or unsubstituted, m Is an integer of 0 to 3. ), A pharmaceutically acceptable salt thereof, or a solvate thereof. |