http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2011068206-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 |
| filingDate | 2010-12-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2013-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-WO2011068206-A1 |
| titleOfInvention | Process for producing optically active amino acid or optically active amino acid amide |
| abstract | The present invention relates to an enzyme that stereoselectively hydrolyzes DL-tert-leucinamide, a microbial cell having the enzyme, a treated product of the microbial cell, and an immobilized enzyme in which the enzyme is immobilized on a carrier. Hydrolysis with the action of a biocatalyst selected from the group consisting of an immobilized microbial cell in which the microbial cell is immobilized on a carrier, and an immobilized microbial cell product in which the treated microbial cell product is immobilized on a carrier To produce D- or L-tert-leucine or D- or L-tert-leucine amide, wherein the hydrolysis is carried out while separating the ammonia produced by the hydrolysis from the hydrolysis reaction solution. It relates to a method characterized in that it is performed. According to the present invention, in an enzymatic reaction for stereoselectively hydrolyzing an amino acid amide, the activity per unit time is maintained high by maintaining the activity per enzyme or bacterial body or its treated product and per unit time. The concentration of the raw material amino acid amide in the reaction solution can be increased without increasing the amount of acid, and as a result, the optically active tert-leucine or optically active tert-leucine amide can be produced without increasing the generation of waste salts and waste cells. Productivity can be greatly improved. |
| priorityDate | 2009-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.