| abstract |
Provided is a method for obtaining an optically active alcohol by suppressing side reactions and highly enantioselective secondary alkylation. The method for producing an optically active alcohol of the present invention comprises (A) a step of reacting zinc halide, metal alkoxide, and RMgY (R: secondary hydrocarbon group, Y: halogen atom) to obtain an organic zinc compound; (B) a step of reacting a carbonyl compound with an organozinc compound in the presence of the phosphoramide compound (1). In step (A), the amount of RMgY is 1 with respect to 1 equivalent of zinc halide. .8 equivalent or less. [Chemical 1] (In Formula (1), R 1 to R 5 are each independently a monovalent hydrocarbon group. R 2 and R 3 are each bonded to a phosphorus atom directly or via an atom other than a carbon atom. X is an oxygen atom or a sulfur atom, A is a methylene group or a carbonyl group.) |