abstract |
To provide a nasal spray vaccine with high preventive effect against human tuberculosis, especially adult tuberculosis. Paramyxovirus genes (especially rhPIV2) that encode α-antigens derived from acid-fast bacteria (for example, those derived from Mycobacterium kansaii or Mycobacterium bovis BCG), analogs thereof, and variants having functions similar to those Achieved with a nasal spray tuberculosis vaccine incorporated in [Selection] Figure 10 |