| abstract |
An object of this invention is to provide the enhancer which can induce | guide | derive osteoblast specific expression, and its use. The present invention provides an approximately 1.3 kb fragment that has a function as an enhancer in the Runx2 gene, in particular and an enhancer described in 0.34 kb, specifically SEQ ID NOs: 1, 3, 4, and 5. The enhancer can activate osteoblast-specific gene transcription by binding to a promoter. |