| abstract |
The present invention provides novel piperidine and pyrrolidine derivatives having NPY Y5 receptor antagonistic activity. Specifically, the present invention provides a compound represented by formula (I), a pharmaceutically acceptable salt thereof or a solvate thereof. [Wherein, A is a substituted or unsubstituted monocyclic aryl or monocyclic heterocyclyl; X is a single bond or C (═O); Y is a single bond, CR 5 R 6 NR 7 or C ( ═O) NR 7 ; R 1 and R 2 are each independently hydrogen or substituted or unsubstituted alkyl; R 3 is substituted or unsubstituted aryl or heterocyclyl; R 4 is halogen Substituted or unsubstituted alkyl, alkoxy, aryloxy, heterocyclyloxy and the like; p is an integer of 0 to 2; q is 0 or 1; m is 0 or 1; n is 0 Is an integer of -5, and B is an aromatic carbocycle, monocyclic heterocycle or bicyclic fused heterocycle. ] |