abstract |
To provide a novel compound exhibiting antitumor activity by inhibiting the interaction between Mdm2 (murine double minute 2) protein and p53 protein. The present invention provides an imidazothiazole derivative represented by the following formula (1) having various substituents that inhibits the interaction between the Mdm2 protein and the p53 protein and exhibits antitumor activity (here, the formula (1) R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , Ar 1 and Ar 2 are the same as defined in the specification. |