| abstract |
Disclosed is a compound useful as an active ingredient of a pharmaceutical composition for treating a disease involving FAAH. As a result of intensive studies on compounds having FAAH inhibitory activity, the present inventors have found that piperazine-1-carboxylate in which benzimidazol-2-ylcarbonyl, benzofuran-2-ylcarbonyl, and the like are bonded to the 4-position of piperazine. Confirmed that the compound has an excellent FAAH inhibitory activity, and also has an effective bladder capacity increasing effect, sleep disorder improving effect, antidiuretic effect, and analgesic effect on lower urinary tract pain such as bladder pain, and completed the present invention. did. The carbamate compound of the present invention has excellent FAAH inhibitory activity and is particularly useful for diseases involving FAAH, particularly nocturia, interstitial cystitis, painful bladder syndrome or chronic non-bacterial prostatitis / chronic pelvic pain syndrome. It can be used as a prophylactic and / or therapeutic agent. [Selection figure] None |