http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2009139191-A1
Outgoing Links
Predicate | Object |
---|---|
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-035 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-00 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
filingDate | 2009-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2011-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | JP-WO2009139191-A1 |
titleOfInvention | Allergic disease model animal |
abstract | An object of the present invention is to provide an allergic disease model mouse such as atopic dermatitis and a dermatitis model mouse having a reduced skin barrier function. The inventors of the present invention have disrupted all or part of the endogenous gene encoding filaggrin by gene mutation such as deletion / replacement and completely lost the function of expressing profilagrin and filaggrin protein, It was found that it can be used as a model mouse for allergic diseases and atopic dermatitis with a reduced skin barrier function. |
priorityDate | 2008-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 394.