| abstract |
The present invention provides a stable metastin derivative having excellent biological activity (cancer metastasis inhibitory activity, cancer growth inhibitory activity, gonadotropin secretion promoting activity, sex hormone secretion promoting activity, etc.). In the metastin derivative of the present invention, the constituent amino acid of metastin is substituted with a specific amino acid, thereby further improving blood stability and solubility, reducing gelation tendency, improving pharmacokinetics, and excellent It exhibits cancer metastasis inhibitory activity and cancer growth inhibitory activity. Furthermore, the metastin derivative of the present invention also has a gonadotropin secretion inhibitory action, a sex hormone secretion inhibitory action, and the like. |