| abstract |
Provided is a novel compound having an excellent MMP inhibitory effect and reduced side effects. General formula (1) (In the formula, R 1 represents (E) -3-phenylallyl group or 3-phenylpropyl group; R 2 represents a hydrogen atom, an isobutyl group, a 2- (4-methoxyphenyl) ethyl group or the like; R 3 represents 1H-indol-3-yl group, 1-naphthyl group or the like; R 4 represents a methyl group, a benzyloxy group, a hydroxy group, a phenethyl group, or the like. The matrix metalloprotease inhibitor which uses the hydroxamic acid derivative represented by these, or its salt as an active ingredient. |