| abstract |
The present invention specifically recognizes human α9 integrin and mouse α9 integrin and recognizes human anti-α9 integrin antibodies or antibody fragments that inhibit their interaction with their ligands, particularly human and mouse α9 integrin loop regions. The antibody or antibody fragment, the gene encoding the antibody or antibody fragment, the recombinant expression vector containing the gene, the transformant introduced with the gene, the human anti-α9 integrin antibody or antibody fragment using the transformant And a prophylactic / therapeutic agent for rheumatoid arthritis comprising the antibody or antibody fragment. |