| abstract |
The present invention provides an amplifying agent for hematopoietic stem cells and / or hematopoietic progenitor cells, which is useful as a treatment method for various hematopoietic diseases and is useful for improving gene transfer efficiency into hematopoietic stem cells during gene therapy. Formula (I) (wherein X, Y, Z, Ar 1 , R 1 , R 2 , R 3 , R 4 , R 5 , R 6 and R 7 are defined in the text). Hematopoietic stem cells and / or hematopoietic progenitor cells are cultured in vitro in the presence of a compound, a tautomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof. And / or a method for amplifying hematopoietic progenitor cells. (Chemical formula 1) |