abstract |
An object of the present invention is to amplify CD34-positive cells in vitro and more efficiently and in a short time by using a low molecular weight compound that can be produced biologically safe and inexpensively. A further object of the present invention is to provide an amplifying agent for CD34 positive cells, which is useful as a treatment method for various hematopoietic diseases associated with dysfunction of hematopoietic stem cells and / or hematopoietic progenitor cells. Formula (I) (wherein A, B, L 1 , L 2 , L 3 , L 4 , R 1 , R 2 , R 3 , X and Y are defined in the text). A method for amplifying CD34-positive cells, comprising culturing CD34-positive cells in vitro in the presence of a compound, a tautomer of the compound, a pharmaceutically acceptable salt thereof, or a solvate thereof. (Chemical formula 1) |