http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2009054240-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2531-0266 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J2231-346 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C303-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B53-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-0239 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-0225 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01J31-0217 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J37-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J31-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01J23-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C309-38 |
| filingDate | 2008-10-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-WO2009054240-A1 |
| titleOfInvention | Method for producing disulfonic acid compound, asymmetric Mannich catalyst, method for producing β-aminocarbonyl derivative, and novel disulfonate |
| abstract | Hexamethylphosphoramide (HMPA) was added to a reaction vessel containing (R) -1,1′-binaphthyl-2,2′-dithiol and potassium hydroxide. Next, the inside of the container was purged with oxygen, and stirred at 80 ° C. for 5 days under 7 atmospheres of oxygen. After cooling to room temperature, purification was performed to obtain potassium (R) -1,1′-binaphthyl-2,2′-disulfonate. (R) -1,1′-binaphthyl-2,2′-disulfonic acid obtained from this disulfonate and 2,6-diphenylpyridine were stirred in acetonitrile, and then the solvent was distilled off under reduced pressure. Thereafter, magnesium sulfate and distilled CH 2 Cl 2 were added, and the mixture was stirred at room temperature for 30 minutes. This solution was cooled to 0 ° C., benzaldehyde imine in which nitrogen was protected with Cbz, and then acetylacetone were added dropwise over 1 hour, and the mixture was further stirred at 0 ° C. for 30 minutes. As a result, the corresponding β-aminocarbonyl derivative was obtained with a yield of 91% and an enantiomeric excess of 90% ee. |
| priorityDate | 2007-10-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 174.