abstract |
As a result of intensive studies on NAD (P) H oxidase inhibitors, the present inventors have found that a quinolone derivative having an alkyl group substituted with a heteroatom at the 2-position has a good NAD (P) H oxidase inhibitory action. As a result, the present invention was completed. Since the compound of the present invention has a reactive oxygen species production inhibitory activity based on the NAD (P) H oxidase inhibitory action, it prevents and / or treats diabetes, impaired glucose tolerance, hyperlipidemia, fatty liver, diabetic complications, etc. It can be used as an agent. [Selection figure] None |