| abstract |
Find compounds having PAI-1 production inhibitory action, tissue fibrosis inhibitory action and fibrinolytic action, tissue fibrosis diseases (pulmonary fibrosis, renal fibrosis etc.), ischemic heart disease (myocardial infarction, angina pectoris), For prevention and / or treatment of diseases caused by pathological thrombus such as intra-atrial thrombus, pulmonary embolism, deep vein thrombosis, disseminated intravascular coagulation, ischemic brain disease (cerebral infarction, cerebral hemorrhage), arteriosclerosis To provide a novel compound useful for. The following general formula (I) Mediated by plasminogen activator inhibitor-1 containing a 5-phenyl-3-pyridazinone derivative represented by the formula: 1) an optical isomer thereof or a pharmaceutically acceptable salt thereof or a hydrate or solvate thereof Provided are medicaments that are useful for the prevention and / or treatment of medical conditions or symptoms. |