| Predicate |
Object |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-626
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-73
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-622
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2833
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39558
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 |
| filingDate |
2008-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate |
2010-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
JP-WO2008111597-A1 |
| titleOfInvention |
Chemotherapeutic drug-resistant cancer therapeutic agent containing an antibody that recognizes HLA class I as an active ingredient, and use thereof |
| abstract |
The present inventors revealed that cytotoxic activity by C3B3 diabody is induced at a lower concentration than the parent strain in a chemotherapeutic drug-resistant hematological tumor cell line that highly expresses MDR1 and HLA class IA proteins. . It was also clarified that when the chemotherapeutic drug-resistant blood tumor cell line was pretreated with C3B3 diabody, the cytotoxicity of the chemotherapeutic agent alone was enhanced and the amount of drug uptake in the cells was increased. That is, it was found that C3B3 diabody exerts antitumor activity and has an action of overcoming drug resistance against MDR1-expressing tumor cells that highly express HLA class I. |
| priorityDate |
2007-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |