| abstract |
To determine an endogenous factor that inhibits hair growth, screen a substance that inhibits the activity or expression of the endogenous factor, and provide a hair growth promoter, hair growth promoter, or alopecia therapeutic agent. FGF18 was found to inhibit hair growth, and a method for screening FGF18 activity inhibitor or FGF18 gene expression inhibitor as a candidate for hair growth promoter, hair growth promoter and alopecia treatment was disclosed. The Also disclosed are hair growth promoters, hair growth promoters or alopecia therapeutic agents containing FGF18 activity inhibitory substances and / or expression inhibitory substances such as partial peptides of FGF18 and bitter gourd hot water extract as active ingredients. |