| abstract |
It is an object of the present invention to provide an antibody having enhanced ADCC activity and a method for producing the same. The present inventors further developed the amino acid mutation of the Fc portion performed by researchers such as Genentech Inc., and cysteine (Cys) is an amino acid that may be accompanied by a significant structural change that cannot be derived from computer search. It was examined whether the ADCC activity could be enhanced by mutating to. The present invention is selected from the group consisting of positions 286, 287, 288, 289, 290, 291, 292, 294, 298, 301, 302, 303, 305, 306, 307, 308 and 309 in the heavy chain constant region. The present invention provides a chimeric antibody in which the amino acid residue in at least one position is changed to Cys. |