| abstract |
The present invention provides a model animal that is useful for elucidating diseases that cause a decrease in bone mass and bone strength, such as osteoporosis, and diseases that cause an increase in bone mass and bone strength, and uses thereof. Specifically, a transgenic animal obtained by introducing an expression vector containing an osteoblast-specific promoter and a gene encoding Bcl-xL, a substance that increases bone mass and / or bone strength using the transgenic animal. A screening method, a screening method for a substance that decreases bone mass and / or bone strength using the transgenic animal, and a bone mass and bone strength increasing agent comprising a gene encoding Bcl-xL or Bcl-xL provide. |