abstract |
The following compounds useful as type I 11β-hydroxysteroid dehydrogenase inhibitors are provided. formula: (Where R 1 is a group represented by the formula: —C (═O) NR 4 R 5 (wherein R 4 and R 5 are each independently hydrogen, optionally substituted alkyl, etc.) or a formula: —NR 6 C (═O) R 7 (wherein R 6 and R 7 are each hydrogen, optionally substituted alkyl, etc.), X and Y are each independently -O- etc. Z is a single bond, etc. R 2 is an optionally substituted alkyl, an optionally substituted alkenyl, etc. R 3 is an optionally substituted alkyl, an optionally substituted alkenyl, etc.), a pharmaceutically acceptable salt thereof, or a solvate thereof. |