| abstract |
The present invention provides a bispecific antibody having a function that exhibits a sufficient effect by itself without co-administering activated lymphocytes (T-LAK). The humanized variable region (5H) and the humanized variable region (5L) of the heavy chain of the anti-human epidermal growth factor receptor 1 antibody 528, and the heavy chain of the anti-CD3 antibody OKT3. A humanized high-functionality two containing a humanized variable region (OH) and a humanized variable region (OL) of a light chain and having the structure of any one of (i) to (vi) according to claim 1 A bispecific antibody, wherein the 5H, 5L, OH, and OL are amino acid sequences shown in SEQ ID NO: 25, SEQ ID NO: 26, SEQ ID NO: 27, and SEQ ID NO: 28, respectively. The humanized highly functional bispecific antibody. |