| abstract |
An object of the present invention is to provide a compound useful as a pharmaceutical agent, which has a binding inhibitory action between S1P and its receptor, Edg-1 (S1P 1 ). Formula (I) [Chemical 1] [In the formula, Ar represents a monocyclic heterocycle containing 1 to 2 nitrogen atoms, A represents an oxygen atom, etc., Y 1 , Y 2 , Y 3 each represents a carbon atom or a nitrogen atom, R 1 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, R 2 represents an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, or the like, and R 3 represents An alkyl group having 1 to 18 carbon atoms, R 4 represents a hydrogen atom, an alkyl group having 1 to 6 carbon atoms, and R 5 represents an alkyl group having 1 to 10 carbon atoms. Or a pharmaceutically acceptable salt thereof. |