abstract |
An object of the present invention is to provide a compound useful as a pharmaceutical agent, which has a binding inhibitory action between S1P and its receptor, Edg-1 (S1P 1 ). Formula {In the formula, A represents an oxygen atom, a sulfur atom, a group represented by the formula -SO-, a group represented by the formula -SO 2- , etc., and R 1 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms. R 1A represents a hydrogen atom, R 2 represents an alkyl group having 1 to 6 carbon atoms, or a cycloalkyl group having 3 to 6 carbon atoms, and R 3 may be substituted. R 4 represents a good aryl group, R 4 represents a hydrogen atom or an alkyl group having 1 to 6 carbon atoms which may be substituted with a carboxyl group, and R 5 represents an alkyl group or carbon atom having 1 to 10 carbon atoms. A cycloalkyl group having a number of 3 to 8 and an aryl group which may be substituted are shown. } Or a pharmaceutically acceptable salt thereof. |