| abstract |
It has been found that the nitrogen-containing heterocyclic derivative represented by the formula (I) specifically binds to the NR1 / NR2B receptor and is used as an analgesic (pain treatment). (In the formula, A 1 has at least one hydroxy and / or amino and may be further substituted with another group, a nitrogen-containing aromatic monocyclic group or a nitrogen-containing aromatic condensed cyclic group, or a ring A nitrogen-containing aromatic monocyclic group or a nitrogen-containing aromatic condensed cyclic group that contains —NH— and may be substituted with other ring atoms, and A 2 has a substituent An aromatic hydrocarbon cyclic group and the like, R 1 and R 2 are each hydrogen or hydroxy, m is 0 or 1, and X is an optionally substituted lower group. alkylene, lower alkenylene, -CO (CR 3 R 4) n -, - CONR 5 (CR 3 R 4) n -, - NR 5 CO (CR 3 R 4) n -, - A 3 - (CR 3 R 4 ) N-etc., R 3 and R 4 are each hydrogen or Is lower alkyl, n and r are each independently 0 to 4, A 3 is phenylene, pyridinylene, etc. Y is a single bond, lower alkylene, —O—, —S— or —NR 15 —. And R 3 to R 15 are each independently hydrogen or lower alkyl optionally having substituent (s), or a pharmaceutically acceptable salt thereof, or a solvate thereof. |