abstract |
The present invention has the formula In the formula, R 1 represents a hydrogen atom, an alkyl group, or the like; R 2 represents a hydrogen atom, an alkyl group, an amino group, or the like; R 3 represents an alkyl group, an alkenyl group, an alkylthio group, or the like, or a Y—X— group. Or R 2 and R 3 may together form a tetramethylene group; X represents a direct bond or a linking group such as CH 2 , CH (OH), S, O, NH, etc. Y represents a substituted or unsubstituted aromatic carbocyclic group, aromatic heterocyclic group, cycloalkyl group, saturated heterocyclic group, etc .; Z represents S or O; n represents 0 or 1-4 Represents an integer of It has a PDE9 inhibitory action, and has overactive bladder, frequent urination, urinary incontinence, dysuria associated with prostatic hypertrophy, urolithiasis, Alzheimer's disease, chronic obstructive pulmonary disease, myocardial infarction, thrombosis, diabetes, etc. The present invention provides a thienopyrimidine derivative or a salt thereof useful in the prevention or treatment of the above. |