| abstract |
The object of the present invention is to search for a receptor based on information on the HN signaling pathway and to find a humanin receptor or a human-like polypeptide receptor (HNR), thereby exerting an activity such as neuroprotective action of HN. Elucidation of mechanisms that promote or suppress intracellular signal transduction, identify related compounds, establish screening methods for HNR agonists and HNR antagonists, and develop therapeutic agents for neurodegenerative diseases, particularly Alzheimer's disease To provide an Alzheimer's disease neuronal cell death assay system, and to provide an HNR gene forced expression method, an intracellular gene knockout method, and the like. Accordingly, the present invention relates to a humanin receptor or humanin-like polypeptide receptor (HNR) comprising at least two proteins selected from the group consisting of gp130 or a partial polypeptide thereof, CNTF-R and WSX-1. |