| abstract |
The present invention relates to identification of a novel cancer prevention / treatment target molecule and a cancer prevention / treatment agent targeting the molecule, ie, SEQ ID NO: 2, SEQ ID NO: 4, SEQ ID NO: 6, SEQ ID NO: 8 or SEQ ID NO: : An antibody against a protein having the same or substantially the same amino acid sequence as the amino acid sequence represented by 10, an antisense polynucleotide of the protein (preferably an siRNA against the mRNA of the protein), expression and / or activity of the protein The present invention provides a cancer cell apoptosis promoting and / or growth inhibitory agent, and a cancer preventive / therapeutic agent comprising a substance that regulates cancer. The present invention also provides a cell apoptosis promoting and / or growth inhibitory substance, cancer preventive / therapeutic substance using the protein (preferably a cell producing it) and an antibody against the protein or a polynucleotide encoding the protein. A screening method is provided. |