abstract |
The present invention relates to a drug screening method using a protein and a compound obtained by the screening method. A compound or salt thereof that inhibits the activity or expression of the protein of the present invention, a neutralizing antibody against the protein, a polynucleotide complementary to the polynucleotide encoding the protein, and the like are prophylactic and / or therapeutic agents for neurodegenerative diseases and the like. Can be used as In addition, the compound or its salt that enhances the activity or expression of the protein of the present invention, the protein or a partial peptide thereof, the polynucleotide encoding the protein, etc. can be used as a preventive and / or therapeutic agent for cancer and the like. . Furthermore, the protein of the present invention is useful as a reagent for screening for compounds that inhibit or enhance the activity of the protein. |