http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-WO2006025525-A1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0639 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5047 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0784 |
| filingDate | 2005-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2008-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-WO2006025525-A1 |
| titleOfInvention | Method for selecting proteins that are likely to present antigens in dendritic cells |
| abstract | Elucidating the mechanism of antigen cross-presentation of dendritic cells, we have clarified that foreign antigens incorporated into dendritic cells are degraded by the proteasome after undergoing polyubiquitination. We found that there is a positive correlation between the amount of antigen protein taken up by dendritic cells and the amount of polyubiquitination and the level of antigen presentation by the antigen protein. Based on these, the amount of antigen protein uptake and polyubiquitinated protein were measured, and a method for predicting the strength of cross-presentation by the antigen protein was born. By using this method, it is possible to select an antigen protein that is easily presented as an antigen from a plurality of proteins. The method of the present invention makes it possible to provide an appropriate cancer immune vaccine by selecting a more appropriate cancer-specific protein. |
| priorityDate | 2004-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 285.