| abstract |
The present invention comprises a core particle containing a drug, an intermediate layer containing an insolubilization accelerator and an insolubilizing substance that are two types of water-soluble components, and a water infiltration amount control layer containing a water-insoluble substance in the outermost layer. The present invention relates to a particulate pharmaceutical composition each contained. INDUSTRIAL APPLICABILITY According to the present invention, a particulate pharmaceutical composition for oral administration capable of suppressing initial drug elution, releasing drug quickly thereafter, and arbitrarily controlling lag time, and intraoral rapid disintegration containing the composition Made it possible to provide locks. Thereby, since the release of the drug in the oral cavity is suppressed, the unpleasant feeling caused by the drug having an unpleasant taste can be reduced and the compliance can be improved. |