| abstract |
The present inventors cloned the 2D7 antigen for the purpose of identifying the antigen of the 2D7 antibody. As a result, it was found that the 2D7 antibody recognizes HLA class IA. In addition, it was examined whether 2D7 antibody has cell death-inducing activity. As a result, it was found that by linking the 2D7 antibody with another antibody, fragmentation of the nucleus was observed and cell death was induced. Furthermore, it was found that the diabody of the 2D7 antibody has a very strong cell death-inducing activity without the addition of another antibody. The above results show that a low molecular weight antibody that recognizes HLA can be used as a cell death inducer. |