| abstract |
The present invention provides a simple process for producing an optically active alcohol of (R) -3-hydroxypentanenitrile, optically active 3-hydroxybutanoic acid ester and optically active 1-phenylethanol derivative, and the above optically active alcohol, The object is to provide a novel enzyme useful for the production of R) -3-hydroxypentanenitrile. The present invention provides an asymmetric reduction of 3-ketopentanenitrile with an optical purity of 99% e.e. e. The above-mentioned novel acetoacetyl CoA reductase capable of producing (R) -3-hydroxypentanenitrile; 3-ketopentanenitrile, acetoacetate ester and 1-phenylethanone derivative, respectively, the novel enzyme or known acetoacetyl CoA In this method, a reductase is allowed to act to produce a corresponding optically active alcohol. |