| abstract |
It can be administered subcutaneously and intravenously, can also be used as a sustained-release preparation, has a high skin permeability, can be used for pharmaceuticals applied to the skin and external preparations and cosmetics as quasi-drugs, Provided is a composition containing retinoic acid nanoparticles with reduced irritation as an active ingredient. Since the polyvalent metal inorganic salt-coated retinoic acid nanoparticles, which are the active ingredients of the present invention, maintain a transparent solution form when dissolved in water, they can be administered as subcutaneous and intravenous injection preparations. . Further, since it is coated with retinoic acid by a coating of a polyvalent metal inorganic salt, it is hypoallergenic and has no characteristics such as occurrence of inflammation and tumorigenesis at the administration site. The polyvalent metal inorganic salt is calcium carbonate, zinc carbonate or calcium phosphate. |