| abstract |
Formula (I) (The symbols in the formula are as described in the specification.) Since the compounds represented by the above, their salts, their solvates, or their prodrugs bind to and antagonize DP receptors, allergic diseases (allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchi Asthma, food allergies, etc.), systemic mastocytosis, systemic mast cell activation disorder, anaphylactic shock, airway contraction, hives, eczema, itching (such as atopic dermatitis, urticaria), itching Diseases (cataracts, retinal detachment, inflammation, infection, sleep disorders, etc.) that occur secondary by behavior (scratching behavior, striking, etc.), inflammation, chronic obstructive pulmonary disease, ischemia-reperfusion injury, cerebrovascular disorder, chronic It is useful for the prevention and / or treatment of diseases such as rheumatoid arthritis, pleurisy, or ulcerative colitis. Moreover, since it binds specifically to the DP receptor and weakly binds to other prostaglandin receptors, a drug with few side effects can be obtained. |