| abstract |
Formula (I) (In the formula, R 1 to R 4 are all hydrogen atoms, or any of R 1 to R 4 is a hydroxyl group and the rest are hydrogen atoms, and R 5 is a linear or cyclic peptide. N is an integer of 10 to 20)), and can inhibit cell adhesion of vascular endothelial cells activated by stimulation with LPS or Lipid A and proliferate against Gram-positive bacteria. Can be suppressed. Therefore, a pharmaceutical composition containing a compound represented by the general formula (I) or a pharmacologically acceptable salt thereof as an active ingredient is caused by activation of vascular endothelial cells or bacterial infection or proliferation. Useful for disease caused. Moreover, since the compound represented by the general formula (I) or a salt thereof can bind to a bacterium having Lipid A, LPS, or LPS as a constituent component, Lipid A, LPS, or LPS contained in the liquid can be bound. It can be an adsorbent useful for removing bacteria as a constituent component. |