| abstract |
An object of the present invention is to provide a differentiation inhibitor capable of culturing stem cells or embryonic stem cells in an undifferentiated state without using feeder cells, a culture method using the same, a culture solution using the same, and this differentiation inhibitor. It is to provide a cell produced by culturing using. According to the present invention, a stem cell differentiation inhibitor comprising a low-molecular compound, particularly a tetrahydroisoquinoline derivative, and a stem cell using a tetrahydroisoquinoline derivative can be used in a large amount, safely and undifferentiated in the absence of feeder cells. Provided are a method for culturing a stem cell, a culture solution for a stem cell containing a tetrahydroisoquinoline derivative, and a cell cultured and produced using the tetrahydroisoquinoline derivative as a differentiation inhibitor. |