| abstract |
Compounds that have capsaicin receptor VR1 activation inhibitory activity and are useful as therapeutic agents for various pains including inflammatory pain, neuropathic pain, migraine, cluster headache, and bladder disease including overactive bladder Offer. The benzene ring is bonded to the D ring (monocyclic or bicyclic hydrocarbon ring, or monocyclic or bicyclic heteroaromatic ring) via an amide bond, and the benzene ring is directly connected to the E ring (monocyclic or bicyclic). A hydrocarbon ring or a monocyclic or bicyclic heteroaromatic ring), and the benzene ring is further bonded to A (amino moiety, monocyclic or bicyclic heterocycle) via L (lower alkylene). A benzamide derivative or a salt thereof. |