| abstract |
The present invention provides a bacteriophage, a lytic enzyme thereof and a ligand for a bacterial surface receptor for a phage preparation effective for prevention and treatment of MRSA and the like, wherein the bacteriophage is a protein consisting of the amino acid sequence of SEQ ID NO: 1. Or (b) consisting of an amino acid sequence in which one or several amino acids in the amino acid sequence of SEQ ID NO: 1 have been deleted, substituted or added, and encodes a protein having Staphylococcus aureus cell wall degrading enzyme activity. An isolated bacteriophage having a DNA sequence of: (c) a DNA sequence encoding a protein consisting of the amino acid sequence of SEQ ID NO: 2 or (d) one or several amino acids in the amino acid sequence of SEQ ID NO: 2 Is a deleted, substituted or added amino acid sequence, which is an isolated bacteriophage having a DNA sequence encoding a protein having the function of a ligand for the bacterial surface receptor of S. aureus. |