| abstract |
formula {Wherein m represents 1 or 2, R1 represents a linear or branched saturated or unsaturated alkyl group having 3 to 8 carbon atoms, a cycloalkyl group having 5 to 8 carbon atoms, A cycloalkenyl group having 5 to 8 carbon atoms, an alkyl group having 1 to 6 carbon atoms, a cycloalkyl group having 3 to 8 carbon atoms, or a cycloalkyl group having 5 to 8 carbon atoms substituted with a phenyl group , trifluoro-butyl group, - perhydronaphthyl group, ยท - (CH 2) -C (CH 3) = group represented by CH-Ph, represents a substituent such as, a cinnamyl group, Z is the formula (Wherein R19 represents a cycloalkyl group having 3 to 10 carbon atoms or a cycloalkenyl group having 3 to 10 carbon atoms), and the like. } Has a high affinity for chemokine receptors, which play an important role in eosinophil infiltration, and inhibits the action of chemokine receptors, thereby inhibiting the action of chemokines in humans and animals. It can be used for treatment or prevention of diseases involving receptors, for example, allergic diseases including bronchial asthma and allergic conjunctivitis. |