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filingDate 2003-04-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2005-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-WO2003087019-A1
titleOfInvention Hyaluronic acid modified product
abstract The present invention is based on a safe hyaluronic acid base suitable for a practical hyaluronic acid preparation that can be distributed at room temperature, has low viscosity, is easy to inject, and stays in the joint cavity for a long time and exhibits analgesic effect. Provide material. More specifically, the present invention relates to hyaluronic acid and / or a pharmaceutically acceptable salt thereof, PEO-PPO-PEO, PPO-PEO-PPO, PEO-PLGA-PEO, PLGA-PEO-PLGA, PEO. -A hyaluronic acid modification product in which a block polymer selected from PLA-PEO and PLA-PEO-PLA is bound is provided. Although the hyaluronic acid modified product of the present invention can be distributed at room temperature and has low viscosity and is easy to handle, it can rapidly increase its viscoelasticity after injection into a living body, and has never been practical. As a main component of the hyaluronic acid preparation, it is very useful for treating joint diseases, assisting in surgery, repairing tissues, and the like.
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