abstract |
The present invention relates to novel isoforms RXRα2 and RXRα3 of the nuclear receptor RXRα. Unlike RXRα1, which is a known isoform, RXRα2 and RXRα increase the transcriptional activation effect by SRC-1. The present invention provides a method for evaluating the function of these RXRα isoforms to regulate the effect of enhancing the transcriptional activation by coactivators, and a screening method based on this evaluation method. By regulating the interaction with each coactivator, it becomes possible to control the transcriptional regulatory activity in an isoform-specific manner. |