abstract |
2-furancarboxylic acid hydrazide compound represented by the following formula (I), a prodrug thereof, a physiologically acceptable salt thereof or a hydrate or solvate thereof, a production method thereof and a pharmaceutical composition containing the same object. [In the formula, A means a group represented by the following formula (a), (Wherein one is cyano R 4 and R 5, nitro, etc., the other is a hydrogen or the like.) One of R 1 and R 2 is a group:-D-a (X) m-R 6, etc. The other is a group: -E- (Y) n-R 7 , hydrogen, aryl, etc., R 3 is hydrogen, D and E are aryl, X and Y are O, R 6 and R 7 Represents alkyl, aryl, arylalkyl, etc., and m and n represent 0 or 1. However, aryl may be substituted. ] The compound has a strong glucagon receptor antagonistic action and is useful as a preventive and / or therapeutic agent for symptoms and diseases involving glucagon. |