| abstract |
A group of proteins that bind to keratin, which is a major component of body hair, and genes encoding them, in particular, hair keratin-associated proteins (KAP) that bind specifically and strongly to hair keratin, genes encoding the same, etc. It is to provide. The authentic chromatin region of human chromosome 21 was determined to have a base sequence of about 33.5 Mb, a dot matrix analysis was performed on the base sequence of the long arm region of chromosome 21 (21q22.3), and homology of the low-frequency repetitive sequence was determined. Search and find 16 KAP genes that are not expressed except in hair root cells. Further, the high frequency repeat sequence existing in the sequence spanning about 1 Mb between the CLDN8 gene and the TIAM1 gene in the region of the long arm of chromosome 21 (21q22.11) is masked, and the presence or absence of a short low frequency repeat sequence is searched for, Find 22 KAP genes. |