| abstract |
The present invention provides the following formula [1] (N represents 0 or 1, X represents CR 4 or N, Y represents CR 6 or N, Z represents CR 7 or N. R 1 and R 2 are the same or different, hydrogen, Represents an optionally substituted alkyl, acyl, an optionally substituted aryl, an optionally substituted aromatic heterocyclic group, etc. R 4 , R 5 , R 6 , R 7 are the same or different Represents hydrogen, halogen, hydroxy, amino, alkyl, haloalkyl, alkoxy, monoalkylamino, dialkylamino, arylalkyl, cyano, nitro, etc. R 3 is an optionally substituted alkylamino, substituted An arylamino which may be substituted, or a cyclic amino which may be substituted, etc.)) or an pharmaceutically acceptable salt thereof, and an active ingredient thereof Composed of a drug composition. The compound of the present invention is useful as a TGF-β antagonist. |