| abstract |
Substances that suppress cell death caused by PARP activation, particularly rheumatoid arthritis, neuronal cell death during cerebral ischemia, cardiac cell death after reperfusion of myocardial infarction, autoimmune destruction of pancreatic islets of Langerhans The present invention provides a method for screening a substance useful as a therapeutic agent and / or preventive agent for inflammatory reaction caused by cell death after shock or immune cell death. Moreover, the novel protein and the novel gene which codes it are provided. The screening method includes a step of contacting a test substance with a cell expressing the LTRPC2 protein under conditions capable of activating the LTRPC2 protein, and a step of analyzing inhibition of activation of the LTRPC2 protein. . The novel proteins are rat and mouse LTRPC2 proteins, and the novel genes are rat and mouse LTRPC2 genes. |